Article
Profiling gene promoter occupancy of Sox2 in two phenotypically distinct breast cancer cell subsets using chromatin immunoprecipitation and genome-wide promoter microarrays.
Breast cancer research : BCR - 8 Nov 2014
Jung Karen, Wang Peng, Gupta Nidhi, Gopal Keshav, Wu Fang, Ye Xiaoxia, Alshareef Abdulraheem, Bigras Gilbert, McMullen Todd P, Abdulkarim Bassam S, Lai Raymond
Abstract excerpt
INTRODUCTION: Aberrant expression of the embryonic stem cell marker Sox2 has been reported in breast cancer (BC). We previously identified two phenotypically distinct BC cell subsets separated based on their differential response to a Sox2 transcription activity reporter, namely the reporter-unresponsive (RU) and the more tumorigenic reporter-responsive (RR) cells. We hypothesized that Sox2, as a transcription...
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