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Article

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

28 Jan 2011

Abstract excerpt

BACKGROUND: The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development. More recently, SOX2 was shown to participate in reprogramming of adult somatic cells to a pluripotent stem cell state and implicated in tumorigenesis in various organs. In breast cancer, SOX2 expression was reported as a feature of...

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PMID: 21276239
DOI: 10.1186/1471-2407-11-42

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