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Article

Membrane Targeting and Stabilization of Sarcospan Is Mediated by the Sarcoglycan Subcomplex

5 Apr 1999

Abstract excerpt

The dystrophin-glycoprotein complex (DGC) is a multisubunit complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. The proteins of the DGC are structurally organized into distinct subcomplexes, and genetic mutations in many individual components are manifested as muscular dystrophy. We recently identified a unique tetraspan-like...

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PMID: 10189375
DOI: 10.1083/jcb.145.1.153

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