The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.

doi:10.1097/YPG.0000000000000279

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The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.

Psychiatric genetics - 1 Jun 2021

Thomas Patrick S, Nielsen Ellen M, Spellicy Catherine J, Harding Mark J, Ye An, Patriquin Michelle, Hamon Sara C, Kosten Thomas R, Nielsen David A

Abstract excerpt

OBJECTIVE: Prior research demonstrated that the δ-opioid receptor (OPRD1) rs678849 variant influences opioid use in African Americans treated with methadone. We examined whether this variant moderated cocaine and opioid use in our clinical cohort of methadone and disulfiram treated recipients. METHODS: Cocaine and opioid codependent patients were stabilized for 2 weeks on methadone and subsequently randomized...

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Identifiers

PMID: 33953123
DOI: 10.1097/YPG.0000000000000279
PMCID: PMC8108700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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