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Article

Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.

PloS one - 1 Jan 2012

Grimley Rachel, Polyakova Oxana, Vamathevan Jessica, McKenary Joanne, Hayes Brian, Patel Champa, Smith Janet, Bridges Angela, Fosberry Andrew, Bhardwaja Anshu, Mouzon Bernadette, Chung Chun-Wa, Barrett Nathalie, Richmond Nicola, Modha Sundip, Solari Roberto

Abstract excerpt

SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellular assays both to assist in drug discovery efforts...

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Identifiers

PMID: 22792191
DOI: 10.1371/journal.pone.0039847
PMCID: PMC3391194

Genes

SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22792191-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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