Sirt1-Independent Mechanisms of the Putative Sirtuin Enzyme Activators SRT1720 and SRT2183

Abstract excerpt

BACKGROUND: SRT1720 and SRT2183 were described recently as activators of the NAD+-dependent deacetylase, SIRT1. These molecules enhanced metabolic function when administered to rodents at doses of 100-500 mg/kg/day, purportedly by activating SIRT1 enzymatic activity in various tissues; however, considerable controversy surrounds these claims. RESULTS: We find that these molecules do not activate SIRT1 deacetylase...

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