Article
RTK signaling modulates the Dorsal gradient.
Development (Cambridge, England) - 1 Aug 2012
Helman Aharon, Lim Bomyi, Andreu María José, Kim Yoosik, Shestkin Tatyana, Lu Hang, Jiménez Gerardo, Shvartsman Stanislav Y, Paroush Ze'ev
Abstract excerpt
The dorsoventral (DV) axis of the Drosophila embryo is patterned by a nuclear gradient of the Rel family transcription factor, Dorsal (Dl), that activates or represses numerous target genes in a region-specific manner. Here, we demonstrate that signaling by receptor tyrosine kinases (RTK) reduces nuclear levels and transcriptional activity of Dl, both at the poles and in the mid-body of the embryo. These effects...
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