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Article

The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.

Genes & development - 1 Apr 1992

Isoda K, Roth S, Nüsslein-Volhard C

Abstract excerpt

The dorsal (dl) protein is a member of the Rel family of transcription factors. It is distributed in a nuclear concentration gradient along the dorsoventral axis of Drosophila embryos and activates or represses a discrete set of zygotic genes in a concentration-dependent manner. The nuclear uptake of the dl protein is stimulated by products of the dorsal group genes but inhibited by the cactus (cact) product. To...

Topics

Alleles
Amino Acids
Animals
DNA
Drosophila
Embryo, Nonmammalian
Heterozygote
Mutation
Phenotype
Transcription, Genetic
Transcriptional Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1559611
DOI: 10.1101/gad.6.4.619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1559611-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.PMID 1559611Read ↗

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.Semantic proximity Read ↗

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.Semantic proximity Read ↗

Specificity of Rel-inhibitor interactions in Drosophila embryos.Semantic proximity Read ↗

Cactus-independent regulation of Dorsal nuclear import by the ventral signal.Semantic proximity Read ↗

RTK signaling modulates the Dorsal gradient.Semantic proximity Read ↗

Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo.Semantic proximity Read ↗

Regulated nuclear import of Rel proteins in the Drosophila immune response.Semantic proximity Read ↗

A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo.Semantic proximity Read ↗

members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation.Semantic proximity Read ↗

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.Semantic proximity Read ↗

Muscle structure and innervation are affected by loss of Dorsal in the fruit fly, Drosophila melanogaster.Semantic proximity Read ↗

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.Semantic proximity Read ↗

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