Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.

Genes & development - 1 Apr 1992

Isoda K, Roth S, Nüsslein-Volhard C

Abstract excerpt

The dorsal (dl) protein is a member of the Rel family of transcription factors. It is distributed in a nuclear concentration gradient along the dorsoventral axis of Drosophila embryos and activates or represses a discrete set of zygotic genes in a concentration-dependent manner. The nuclear uptake of the dl protein is stimulated by products of the dorsal group genes but inhibited by the cactus (cact) product. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acids
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Heterozygote

Share to Mutation

Share to Phenotype

Share to Transcription, Genetic

Source

Identifiers

PMID: 1559611
DOI: 10.1101/gad.6.4.619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.PMID 1559611Read ↗

cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.Semantic proximity Read ↗

A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila.Semantic proximity Read ↗

Specificity of Rel-inhibitor interactions in Drosophila embryos.Semantic proximity Read ↗

Cactus-independent regulation of Dorsal nuclear import by the ventral signal.Semantic proximity Read ↗

RTK signaling modulates the Dorsal gradient.Semantic proximity Read ↗

Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo.Semantic proximity Read ↗

Regulated nuclear import of Rel proteins in the Drosophila immune response.Semantic proximity Read ↗

A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo.Semantic proximity Read ↗

members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation.Semantic proximity Read ↗

Cactus protein degradation mediates Drosophila dorsal-ventral signaling.Semantic proximity Read ↗

Muscle structure and innervation are affected by loss of Dorsal in the fruit fly, Drosophila melanogaster.Semantic proximity Read ↗

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.