Article
lolal Is an Evolutionarily New Epigenetic Regulator of dpp Transcription during Dorsal-Ventral Axis Formation.
Molecular biology and evolution - 1 Oct 2016
Quijano Janine C, Wisotzkey Robert G, Tran Nancy Lan, Huang Yunxian, Stinchfield Michael J, Haerry Theodor E, Shimmi Osamu, Newfeld Stuart J
Abstract excerpt
Secreted ligands in the Dpp/BMP family drive dorsal-ventral (D/V) axis formation in all Bilaterian species. However, maternal factors regulating Dpp/BMP transcription in this process are largely unknown. We identified the BTB domain protein longitudinals lacking-like (lolal) as a modifier of decapentaplegic (dpp) mutations. We show that Lolal is evolutionarily related to the Trithorax group of chromatin...
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