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Article

Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice.

The American journal of pathology - 1 Aug 2007

Lu Zhi Hong, Wright Jason D, Belt Brian, Cardiff Robert D, Arbeit Jeffrey M

Abstract excerpt

Advanced cervical cancer remains a vexing clinical challenge despite screening programs. Many of these cancers are hypoxic, and expression of the alpha subunit of the major regulator of the hypoxic cellular response, the transcription factor hypoxia-inducible factor-1 (HIF-1), is correlated with poor prognosis. Here, we tested a functional role for HIF-1alpha in pathogenesis of cervical cancer in estrogen-treated...

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Identifiers

PMID: 17600126
DOI: 10.2353/ajpath.2007.061138
PMCID: PMC1934541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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