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Article

PTTG1 attenuates drug-induced cellular senescence.

PloS one - 1 Jan 2011

Tong Yunguang, Zhao Weijiang, Zhou Cuiqi, Wawrowsky Kolja, Melmed Shlomo

Abstract excerpt

As PTTG1 (pituitary tumor transforming gene) abundance correlates with adverse outcomes in cancer treatment, we determined mechanisms underlying this observation by assessing the role of PTTG1 in regulating cell response to anti-neoplastic drugs. HCT116 cells devoid of PTTG1 (PTTG1(-/-)) exhibited enhanced drug sensitivity as assessed by measuring BrdU incorporation in vitro. Apoptosis, mitosis catastrophe or DNA...

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Source

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Identifiers

PMID: 21858218
DOI: 10.1371/journal.pone.0023754
PMCID: PMC3157437

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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