Computational studies on the prion protein.

Abstract excerpt

Prion diseases are rare neurodegenerative diseases characterized by the conversion of the prion protein from its native state (PrP(C)) towards the so-called 'scrapie form', rich in β-strands. Computational approaches, here briefly reviewed, are instrumental to understand the intrinsic instability of PrP(C) fold and how the latter is affected by mutations, binding of metals as well as by different environmental...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hydrogen-Ion Concentration
• Share to Models, Molecular
• Share to Molecular Dynamics Simulation