Article
High affinity binding between copper and full-length prion protein identified by two different techniques.
The Journal of biological chemistry - 30 Dec 2005
Thompsett Andrew R, Abdelraheim Salama R, Daniels Maki, Brown David R
Abstract excerpt
The cellular prion protein is known to be a copper-binding protein. Despite the wide range of studies on the copper binding of PrP, there have been no studies to determine the affinity of the protein on both full-length prion protein and under physiological conditions. We have used two techniques, isothermal titration calorimetry and competitive metal capture analysis, to determine the affinity of copper for wild...
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