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Article

Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes.

The Journal of biological chemistry - 1 Apr 2022

Daude Nathalie, Lau Agnes, Vanni Ilaria, Kang Sang-Gyun, Castle Andrew R, Wohlgemuth Serene, Dorosh Lyudmyla, Wille Holger, Stepanova Maria, Westaway David

Abstract excerpt

The cellular prion protein (PrPC) has a C-terminal globular domain and a disordered N-terminal region encompassing five octarepeats (ORs). Encounters between Cu(II) ions and four OR sites produce interchangeable binding geometries; however, the significance of Cu(II) binding to ORs in different combinations is unclear. To understand the impact of specific binding geometries, OR variants were designed that...

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Identifiers

PMID: 35271850
DOI: 10.1016/j.jbc.2022.101770
PMCID: PMC9010764

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