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Article

The expanded octarepeat domain selectively binds prions and disrupts homomeric prion protein interactions.

The Journal of biological chemistry - 10 Feb 2006

Leliveld Sirik Rutger, Dame Remus Thei, Wuite Gijs J L, Stitz Lothar, Korth Carsten

Abstract excerpt

Insertion of additional octarepeats into the prion protein gene has been genetically linked to familial Creutzfeldt Jakob disease and hence to de novo generation of infectious prions. The pivotal event during prion formation is the conversion of the normal prion protein (PrPC) into the pathogenic conformer PrPSc, which subsequently induces further conversion in an autocatalytic manner. Apparently, an expanded...

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Identifiers

PMID: 16352600
DOI: 10.1074/jbc.M510606200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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