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Article

Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.

Blood - 23 Aug 2012

Huang Xin, Yan Yahui, Tu Yizheng, Gatti Jeffrey, Broze George J, Zhou Aiwu, Olson Steven T

Abstract excerpt

The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPI-binding interface,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22786881
DOI: 10.1182/blood-2012-03-419598
PMCID: PMC3429311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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