Article
Protein Z, an anticoagulant protein with expanding role in reproductive biology.
Reproduction (Cambridge, England) - 1 Aug 2013
Almawi Wassim Y, Al-Shaikh Fatima S, Melemedjian Ohannes K, Almawi Ahmad W
Abstract excerpt
Protein Z (PZ) is a vitamin K-dependent factor characterized by its homology to other vitamin K-dependent factors (factors VII, IX, and X, protein C and protein S), but lacks any enzymatic activity. Instead, PZ acts as a cofactor for the inhibition of factor Xa through the serpin PZ-dependent protease inhibitor (ZPI). PZ deficiency is associated with a procoagulant state, highlighted by excessive FXa secretion...
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