Article
[Protein Z: a new regulator of coagulation in arterial vessels?].
Annales pharmaceutiques francaises - 1 Sept 2004
Vasse M, Denoyelle Chr, Guégan-Massardier E, Legrand E, Borg J-Y, Lenormand B, Soria Cl, Vannier J-P
Abstract excerpt
Protein Z (PZ) is a vitamin K dependent factor identified in human plasma in 1984 whose physiological function was poorly understood. It was recently shown that protein Z is implicated in the down-regulation of coagulation by forming a complex with a plasma proteinase inhibitor called protein Z-dependent protease inhibitor (ZPI) which inhibits activated factor Xa on phospholipid surfaces. In the absence of an...
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