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Article

Tapping Into the Natural PZ-Independent Anticoagulant Function of ZPI to Inhibit Thrombosis With Minimal Effect on Hemostasis.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2025

Huang Xin, Swanson Richard, Wang Can, Du Xiaoping

Abstract excerpt

BACKGROUND: The protein ZPI (Z-dependent protease inhibitor) binds to PZ (protein Z), which enables ZPI to inhibit membrane-bound FXa (activated factor X). ZPI also inhibits FXIa (activated factor XI) independently of PZ. METHODS: To study the PZ-independent ZPI function, we tested the in vitro and in vivo effect of disrupting the ZPI-PZ interaction by mutating ZPI Asp 293 to Ala (D293A). RESULTS: D293A mutation...

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PMID: 39973748
DOI: 10.1161/ATVBAHA.124.321329
PMCID: PMC12018148

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