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Article

Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z.

Biochimica et biophysica acta - 1 Sept 2014

Qureshi Shabir H, Lu Qiuya, Manithody Chandrashekhara, Yang Likui, Rezaie Alireza R

Abstract excerpt

BACKGROUND: Protein Z (PZ) has been reported to promote the inactivation of factor Xa (FXa) by PZ-dependent protease inhibitor (ZPI) by about three orders of magnitude. Previously, we prepared a chimeric PZ in which its C-terminal pseudo-catalytic domain was grafted on FX light-chain (Gla and EGF-like domains) (PZ/FX-LC). Characterization of PZ/FX-LC revealed that the ZPI interactive-site is primarily located...

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Identifiers

PMID: 24960590
DOI: 10.1016/j.bbapap.2014.06.011
PMCID: PMC4118583

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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