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Mildronate improves cognition and reduces amyloid‐β pathology in transgenic Alzheimer's disease mice

22 Nov 2013

Abstract excerpt

Mildronate, a carnitine congener drug, previously has been shown to provide neuroprotection in an azidothymidine-induced mouse model of neurotoxicity and in a Parkinson's disease rat model. The aim of this study was to investigate the effects of mildronate treatment on cognition and pathology in Alzheimer's disease (AD) model mice (APP(SweDI)). Mildronate was administered i.p. daily at 50 or 100 mg/kg for 28...

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PMID: 24273007
DOI: 10.1002/jnr.23315

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