Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster.

The Journal of experimental biology - 1 Aug 2012

Chahine Sarah, Campos Ana, O'Donnell Michael J

Abstract excerpt

Insects excrete a wide variety of toxins via the Malpighian (renal) tubules. Previous studies have implicated three transporters in the secretion of the organic anion (OA) methotrexate (MTX) by the Drosophila Malpighian tubule: Drosophila multidrug resistance-associated protein (dMRP, CG6214), a multidrug efflux transporter (MET, CG30344), and an organic anion transporting polypeptide 58Dc (OATP58Dc, CG3380). RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Genes, Insect

Share to Ion Transport

Share to Methotrexate

Share to Multidrug Resistance-Associated Proteins

Share to Organic Anion Transporters

Source

Identifiers

PMID: 22786636
DOI: 10.1242/jeb.071100

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster.PMID 22786636Read ↗

The Malpighian tubule: rapid insights from post-genomic biology.Semantic proximity Read ↗

The effects of altered expression of the Keap1/CncC pathway on the secretion of fluid and salicylate by Malpighian tubules of Drosophila melanogasterSemantic proximity Read ↗

Insights into the Malpighian tubule from functional genomics.Semantic proximity Read ↗

The Drosophila Malpighian tubule as a model for mammalian tubule functionSemantic proximity Read ↗

Drosophila TRPM channel is essential for the control of extracellular magnesium levels.Semantic proximity Read ↗

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.Semantic proximity Read ↗

Identification of multiple functional receptors for tyramine on an insect secretory epithelium.Semantic proximity Read ↗

The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance‐associated protein familySemantic proximity Read ↗

Effects of lithium on mortality and metabolite profiles in Drosophila lithium-inducible SLC6 transporter mutants.Semantic proximity Read ↗

Salt stress alters fluid and ion transport by Malpighian tubules of Drosophila melanogaster: evidence for phenotypic plasticity.Semantic proximity Read ↗

Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene.Semantic proximity Read ↗

Mutation of a novel ABC transporter gene is responsible for the failure to incorporate uric acid in the epidermis of ok mutants of the silkworm, Bombyx mori.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.