Article

The effects of altered expression of the Keap1/CncC pathway on the secretion of fluid and salicylate by Malpighian tubules of Drosophila melanogaster

2016-09-01

Abstract excerpt

The Keap1‐Nrf2 pathway is a major upstream regulator of xenobiotic detoxification. In Drosophila melanogaster Meigen, targeted expression of Keap1 and CncC (the latter the orthologue of human Nrf2) in the Malpighian (renal) tubules is known to confer resistance to lethal doses of the pesticide malathion, which is metabolized into organic anions. Dietary exposure to organic anions such as salicylate (10 mm) causes...

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Literature Corpus work: 4d340507-ce89-5687-8725-5bc6e07a01bb
DOI: 10.1111/phen.12144

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