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Article

Regulation of protein secretion into bile: studies in mice with a disrupted mdr2 p-glycoprotein gene.

Gastroenterology - 1 Dec 1995

Groen A K, Van Wijland M J, Frederiks W M, Smit J J, Schinkel A H, Oude Elferink R P

Abstract excerpt

BACKGROUND & AIMS: Protein is secreted into bile via several independent pathways. The aim of this study was to investigate whether these pathways are influenced by secretion of biliary lipid. METHODS: Protein secretion and biliary lipid output were studied in wild-type mice (+/+), heterozygotes (+/-), and homozygotes (-/-) for mdr2 gene disruption. Biliary lipid and protein output were varied by infusion with...

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PMID: 7498666
DOI: 10.1016/0016-5085(95)90768-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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