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Article

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice.

Histochemistry and cell biology - 1 Nov 2012

Herrnberger Leonie, Seitz Roswitha, Kuespert Sabrina, Bösl Michael R, Fuchshofer Rudolf, Tamm Ernst R

Abstract excerpt

Plasmalemmal vesicle-associated protein (PLVAP, PV-1) is specifically expressed in endothelial cells in which it localizes to diaphragms of fenestrae, caveolae, and transendothelial channels. To learn about its function, we generated mutant mice that lack PLVAP. In a C57BL/6N genetic background, homozygous Plvap-deficient embryos die before birth and suffer from subcutaneous edema, hemorrhages, and defects in the...

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Source

Identifiers

PMID: 22782339
DOI: 10.1007/s00418-012-0987-3

Genes

PLVAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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