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Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

24 Apr 2014

Abstract excerpt

Autosomal dominant polycystic kidney disease is a common form of inherited kidney disease that is caused by mutations in two genes, PKD1 (polycystin-1) and PKD2 (polycystin-2). Mice with germline deletion of either gene die in midgestation with a vascular phenotype that includes profound edema. Although an endothelial cell defect has been suspected, the basis of this phenotype remains poorly understood. Here, we...

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PMID: 24767998
DOI: 10.1016/j.celrep.2014.03.064

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