Article
The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis.
Development (Cambridge, England) - 2 Dec 2019
Gordon Ludmila, Blechman Janna, Shimoni Eyal, Gur Dvir, Anand-Apte Bela, Levkowitz Gil
Abstract excerpt
To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be...
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