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Article

Generation of Plvap-CreER and Car4-CreER for genetic targeting of distinct lung capillary populations.

Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2022

Zhang Zhenqian, Zhou Bin

Abstract excerpt

It has been reported recently that there are two distinct subpopulations of capillary endothelial cells in the mammalian lungs: gCap (general capillary) and aCap (aerocyte). They are identified by two unique markers, respectively: plasmalemmal vesicle-associated protein (PLVAP) and carbonic anhydrase IV (CAR4). Here, we report two novel knock-in mouse lines Plvap-CreER and Car4-CreER, which genetically target...

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PMID: 36028133
DOI: 10.1016/j.jgg.2022.08.001

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