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Article

Polycystin 1 is required for the structural integrity of blood vessels.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout M A

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD), often caused by mutations in the PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly attributed to the frequent occurrence of hypertension. A previously reported targeted mutation of the mouse homologue of PKD1 was not associated with vascular fragility, leading to the suggestion that the vascular lesion may be of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Endothelium, Vascular

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Source

Open in PubMed Open full text

Identifiers

PMID: 10677526
DOI: 10.1073/pnas.040550097
PMCID: PMC26504

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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