Article
Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017
Bianchi Roberta, Russo Erica, Bachmann Samia B, Proulx Steven T, Sesartic Marko, Smaadahl Nora, Watson Steve P, Buckley Christopher D, Halin Cornelia, Detmar Michael
Abstract excerpt
OBJECTIVE: The lymphatic vascular system exerts major physiological functions in the transport of interstitial fluid from peripheral tissues back to the blood circulation and in the trafficking of immune cells to lymph nodes. Previous studies in global constitutive knockout mice for the lymphatic transmembrane molecule podoplanin reported perinatal lethality and a complex phenotype with lung abnormalities,...
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