Structure-based mutant stability predictions on proteins of unknown structure.

doi:10.1016/j.jbiotec.2012.06.020

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Article

Structure-based mutant stability predictions on proteins of unknown structure.

Journal of biotechnology - 31 Oct 2012

Gonnelli Giulia, Rooman Marianne, Dehouck Yves

Abstract excerpt

The ability to rapidly and accurately predict the effects of mutations on the physicochemical properties of proteins holds tremendous importance in the rational design of modified proteins for various types of industrial, environmental or pharmaceutical applications, as well as in elucidating the genetic background of complex diseases. In many cases, the absence of an experimentally resolved structure represents...

Topics

Amino Acid Sequence
Databases, Protein
Models, Molecular
Mutant Proteins
Mutation
Protein Stability
Structure-Activity Relationship
Thermodynamics

Source

Open in PubMed

Identifiers

PMID: 22782143
DOI: 10.1016/j.jbiotec.2012.06.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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