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Article

Computational Modeling of Protein Stability: Quantitative Analysis Reveals Solutions to Pervasive Problems.

Structure (London, England : 1993) - 2 Jun 2020

Broom Aron, Trainor Kyle, Jacobi Zachary, Meiering Elizabeth M

Abstract excerpt

Accurate modeling of the effects of mutations on protein stability is central to understanding and controlling proteins in myriad natural and applied contexts. Here, we reveal through rigorous quantitative analysis that stability prediction tools often favor mutations that increase stability at the expense of solubility. Moreover, while these tools may accurately identify strongly destabilizing mutations, the...

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Identifiers

PMID: 32375024
DOI: 10.1016/j.str.2020.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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