Article
Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures.
Briefings in bioinformatics - 10 Mar 2022
Pan Qisheng, Nguyen Thanh Binh, Ascher David B, Pires Douglas E V
Abstract excerpt
Changes in protein sequence can have dramatic effects on how proteins fold, their stability and dynamics. Over the last 20 years, pioneering methods have been developed to try to estimate the effects of missense mutations on protein stability, leveraging growing availability of protein 3D structures. These, however, have been developed and validated using experimentally derived structures and biophysical...
Topics
- Computational Biology
- Databases, Protein
- Mutation
- Protein Stability
- Proteins
- Reproducibility of Results