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Article

Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables.

Protein engineering - 1 Jan 1997

Topham C M, Srinivasan N, Blundell T L

Abstract excerpt

An approach to the prediction of mutant stability is described using knowledge of amino acid replacements that are tolerated within the families of homologous proteins of known 3-D structure. Amino acid variations in families of homologous proteins are converted to propensity and substitution tables; these provide quantitative information about the existence of an amino acid in a structural environment and the...

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Identifiers

PMID: 9051729
DOI: 10.1093/protein/10.1.7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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