Article
Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables.
Protein engineering - 1 Jan 1997
Topham C M, Srinivasan N, Blundell T L
Abstract excerpt
An approach to the prediction of mutant stability is described using knowledge of amino acid replacements that are tolerated within the families of homologous proteins of known 3-D structure. Amino acid variations in families of homologous proteins are converted to propensity and substitution tab...
Topics
- Algorithms
- Amino Acid Sequence
- Amino Acids
- Drug Stability
- Forecasting
- Mutation
- Protein Conformation
- Regression Analysis
- Thermodynamics