Article
Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands.
Brain research - 20 May 2013
Gaven Florence, Pellissier Lucie P, Queffeulou Emilie, Cochet Maud, Bockaert Joël, Dumuis Aline, Claeysen Sylvie
Abstract excerpt
G protein-coupled receptors (GPCRs) can activate simultaneously multiple signaling pathways upon agonist binding. The combined use of engineered GPCRs, such as the receptors activated solely by synthetic ligands (RASSLs), and of biased ligands that activate only one pathway at a time might help deciphering the physiological role of each G protein signaling. In order to find serotonin type 4 receptor (5-HT₄R)...
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