Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.

Journal of the American Chemical Society - 12 Sept 2012

Daeffler Kristina N-M, Lester Henry A, Dougherty Dennis A

Abstract excerpt

The recently published crystal structure of the D3 dopamine receptor shows a tightly packed region of aromatic residues on helices 5 and 6 in the space bridging the binding site and what is thought to be the origin of intracellular helical motion. This highly conserved region also makes contacts with residues on helix 3, and here we use double mutant cycle analysis and unnatural amino acid mutagenesis to probe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Models, Molecular
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Oocytes

Share to Receptors, Dopamine D2

Share to Sulfur

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 22897614
DOI: 10.1021/ja304560x
PMCID: PMC3461201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.PMID 22897614Read ↗

A coupled array of noncovalent interactions impacts the function of the 5-HT3A serotonin receptor in an agonist-specific way.Semantic proximity Read ↗

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms.Semantic proximity Read ↗

Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine.Semantic proximity Read ↗

Investigating the structural impact of S311C mutation in DRD2 receptor by molecular dynamics & docking studies.Semantic proximity Read ↗

Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.Semantic proximity Read ↗

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.Semantic proximity Read ↗

Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations.Semantic proximity Read ↗

Reciprocal mutations in TM2/TM3 in a D2 dopamine receptor background confirms the importance of this microdomain as a selective determinant of para-halogenated 1,4-disubstituted aromatic piperazines.Semantic proximity Read ↗

A triad of residues is functionally transferrable between 5-HT3 serotonin receptors and nicotinic acetylcholine receptors.Semantic proximity Read ↗

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.Semantic proximity Read ↗

Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating.Semantic proximity Read ↗

Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.