Article
PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations.
Oncogene - 16 May 2013
Yao Z, Jones A W E, Fassone E, Sweeney M G, Lebiedzinska M, Suski J M, Wieckowski M R, Tajeddine N, Hargreaves I P, Yasukawa T, Tufo G, Brenner C, Kroemer G, Rahman S, Szabadkai G
Abstract excerpt
Primary mitochondrial dysfunction commonly leads to failure in cellular adaptation to stress. Paradoxically, however, nonsynonymous mutations of mitochondrial DNA (mtDNA) are frequently found in cancer cells and may have a causal role in the development of resistance to genotoxic stress induced by common chemotherapeutic agents, such as cis-diammine-dichloroplatinum(II) (cisplatin, CDDP). Little is known about...
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