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Article

Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.

Oncology reports - 1 Feb 2022

Horibe Sayo, Ishikawa Kaori, Nakada Kazuto, Wake Masaki, Takeda Norihiko, Tanaka Toru, Kawauchi Shoji, Sasaki Naoto, Rikitake Yoshiyuki

Abstract excerpt

The efficacy of cisplatin (CDDP) has been demonstrated in the treatment of various cancers as monotherapy and combination therapy with immunotherapy. However, acquired CDDP resistance is a major obstacle to successful treatment. In the present study, the mechanisms underlying acquired CDDP resistance were examined using ACR20 cells, which are CDDP‑resistant cells derived from A549 lung cancer cells. CDDP induces...

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Source

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Identifiers

PMID: 34935060
DOI: 10.3892/or.2021.8243
PMCID: PMC8717125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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