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Article

Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization.

Human molecular genetics - 1 Aug 2017

Girolimetti Giulia, Guerra Flora, Iommarini Luisa, Kurelac Ivana, Vergara Daniele, Maffia Michele, Vidone Michele, Amato Laura Benedetta, Leone Giulia, Dusi Sabrina, Tiranti Valeria, Perrone Anna Myriam, Bucci Cecilia, Porcelli Anna Maria, Gasparre Giuseppe

Abstract excerpt

Development of chemoresistance is a cogent clinical issue in oncology, whereby combination of anticancer drugs is usually preferred also to enhance efficacy. Paclitaxel (PTX), combined with carboplatin, represents the standard first-line chemotherapy for different types of cancers. We here depict a double-edge role of mitochondrial DNA (mtDNA) mutations induced in cancer cells after treatment with platinum. MtDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28486623
DOI: 10.1093/hmg/ddx186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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