Article
How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.
Mutation research. Reviews in mutation research - 1 Jan 2000
van Gisbergen M W, Voets A M, Starmans M H W, de Coo I F M, Yadak R, Hoffmann R F, Boutros P C, Smeets H J M, Dubois L, Lambin P
Abstract excerpt
Several mutations in nuclear genes encoding for mitochondrial components have been associated with an increased cancer risk or are even causative, e.g. succinate dehydrogenase (SDHB, SDHC and SDHD genes) and iso-citrate dehydrogenase (IDH1 and IDH2 genes). Recently, studies have suggested an eminent role for mitochondrial DNA (mtDNA) mutations in the development of a wide variety of cancers. Various studies...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.