Article
Mutations in the large subunit of U2AF disrupt pre-mRNA splicing, cell cycle progression and nuclear structure.
Yeast (Chichester, England) - 1 Aug 2000
Beales M, Flay N, McKinney R, Habara Y, Ohshima Y, Tani T, Potashkin J
Abstract excerpt
The prp2 gene of fission yeast has previously been shown to encode the large subunit of the splicing factor spU2AF. SpU2AF(59) is an evolutionarily conserved protein that has an arginine/serine-rich region and three RNA recognition motifs (RRMs). We have sequenced three temperature-sensitive alleles of prp2 and determined that the mutations result in single amino acid changes within one of the RRMs or between...
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