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Article

Brm inhibits the proliferative response of keratinocytes and corneal epithelial cells to ultraviolet radiation-induced damage.

PloS one - 1 Jan 2014

Hassan Nur Mohammad Monsur, Painter Nicole, Howlett C Rolfe, Farrell Andrew W, Di Girolamo Nick, Lyons J Guy, Halliday Gary M

Abstract excerpt

Ultraviolet radiation (UV) from sunlight is the primary cause of skin and ocular neoplasia. Brahma (BRM) is part of the SWI/SNF chromatin remodeling complex. It provides energy for rearrangement of chromatin structure. Previously we have found that human skin tumours have a hotspot mutation in BRM and that protein levels are substantially reduced. Brm-/- mice have enhanced susceptibility to photocarcinogenesis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium, Corneal

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Source

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Identifiers

PMID: 25254962
DOI: 10.1371/journal.pone.0107931
PMCID: PMC4177874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Brm inhibits the proliferative response of keratinocytes and corneal epithelial cells to ultraviolet radiation-induced damage.PMID 25254962Read ↗

The absence of Brm exacerbates photocarcinogenesis.Semantic proximity Read ↗

BRM and BRG1 subunits of the SWI/SNF chromatin remodelling complex are downregulated upon progression of benign skin lesions into invasive tumoursSemantic proximity Read ↗

Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.Semantic proximity Read ↗

Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.Semantic proximity Read ↗

Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesisSemantic proximity Read ↗

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic neviSemantic proximity Read ↗

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Epidermal proliferation but not quantity of DNA photodamage is correlated with UV-induced mouse skin carcinogenesis.Semantic proximity Read ↗

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Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.Semantic proximity Read ↗

The Activity of p53 Is Differentially Regulated by Brm- and Brg1-containing SWI/SNF Chromatin Remodeling ComplexesSemantic proximity Read ↗

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