Article
Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.
The Journal of biological chemistry - 15 Feb 2002
Strobeck Matthew W, Reisman David N, Gunawardena Ranjaka W, Betz Bryan L, Angus Steven P, Knudsen Karen E, Kowalik Timothy F, Weissman Bernard E, Knudsen Erik S
Abstract excerpt
The BRG-1 subunit of the SWI-SNF complex is involved in chromatin remodeling and has been implicated in the action of the retinoblastoma tumor suppressor (RB). Given the importance of BRG-1 in RB function, germ line BRG-1 mutations in tumorigenesis may be tantamount to RB inactivation. Therefore, in this study we assessed the behavior of cells harboring discrete BRG-1 alleles for the RB-signaling pathway. Using...
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