Article
Association of P2Y(2) receptor SNPs with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.
Purinergic signalling - 1 Mar 2013
Wesselius Anke, Bours Martijn J L, Henriksen Zanne, Syberg Susanne, Petersen Solveig, Schwarz Peter, Jørgensen Niklas R, van Helden Svenhjalmar, Dagnelie Pieter C
Abstract excerpt
The P2Y(2) receptor is a G-protein-coupled receptor with adenosine 5'-triphosphate (and UTP) as natural ligands. It is thought to be involved in bone physiology in an anti-osteogenic manner. As several non-synonymous single nucleotide polymorphisms (SNPs) have been identified within the P2Y(2) receptor gene in humans, we examined associations between genetic variations in the P2Y(2) receptor gene and bone mineral...
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