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Article

Role of purinergic receptor polymorphisms in human bone.

Frontiers in bioscience (Landmark edition) - 1 Jun 2011

Wesselius Anke, Bours Martijn J L, Agrawal Ankita, Gartland Alison, Dagnelie Pieter C, Schwarz Peter, Jorgensen Niklas R

Abstract excerpt

Osteoporosis is a multifactorial disease with a strong genetic component. Variations in a number of genes have been shown to associate with bone turnover and risk of osteoporosis. P2 purinergic receptors are proteins that have ATP or other nucleotides as their natural ligands. Various P2Y and P2X receptor subtypes have been identified on bone cells. Several cellular functions in bone tissue are coupled to...

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PMID: 21622196
DOI: 10.2741/3873

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