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Article

Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage

25 Feb 2008

Abstract excerpt

The zinc finger transcription factor GATA-1 requires direct physical interaction with the cofactor friend of GATA-1 (FOG-1) for its essential role in erythroid and megakaryocytic development. We show that in the mast cell lineage, GATA-1 functions completely independent of FOG proteins. Moreover, we demonstrate that FOG-1 antagonizes the fate choice of multipotential progenitor cells for the mast cell lineage,...

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PMID: 18299398
DOI: 10.1084/jem.20070544

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