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Article

Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors.

Scientific reports - 1 Jan 2012

Takeda Takaaki, Okuyama Hiroaki, Nishizawa Yasuko, Tomita Shuhei, Inoue Masahiro

Abstract excerpt

In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased invasion into surrounding exocrine tissue. Double KO mice of Vegf and hypoxia inducible factor-1α (Hif-1α) showed increased life span and suppressed tumor growth due to increased apoptosis. The increased invasiveness of tumors in VKO mice...

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Source

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Identifiers

PMID: 22768384
DOI: 10.1038/srep00494
PMCID: PMC3389366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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