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Article

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation.

Journal of the National Cancer Institute - 16 Jun 2004

Stoeltzing Oliver, McCarty Marya F, Wey Jane S, Fan Fan, Liu Wenbiao, Belcheva Anna, Bucana Corazon D, Semenza Gregg L, Ellis Lee M

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor 1 (HIF-1), a heterodimer comprising the oxygen-regulated subunit, HIF-1alpha, and HIF-1beta, mediates transcription of the gene for vascular endothelial growth factor (VEGF). Overexpression of HIF-1alpha is associated with tumor angiogenesis and tumor cell proliferation and invasion. We examined the effects of inhibiting HIF-1alpha activity on angiogenesis and human gastric...

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Identifiers

PMID: 15199114
DOI: 10.1093/jnci/djh168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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