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Article

Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Cheng Nikki, Brantley Dana, Fang Wei Bin, Liu Hua, Fanslow William, Cerretti Douglas Pat, Bussell Katrin N, Reith Alastair, Jackson Dowdy, Chen Jin

Abstract excerpt

Elevated expression of Eph receptors has long been correlated with the growth of solid tumors. However, the functional role of this family of receptor tyrosine kinases in carcinogenesis and tumor angiogenesis has not been well characterized. Here we report that soluble EphA receptors inhibit tumor angiogenesis and tumor progression in vivo in the RIP-Tag transgenic model of vascular endothelial growth factor...

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Identifiers

PMID: 14670182
DOI: 10.1016/s1476-5586(03)80047-7
PMCID: PMC1502614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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