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Article

Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis.

PloS one - 1 Jan 2012

Tsukuda Yukinori, Iwasaki Norimasa, Seito Naoki, Kanayama Masashi, Fujitani Naoki, Shinohara Yasuro, Kasahara Yasuhiko, Onodera Tomohiro, Suzuki Koji, Asano Tsuyoshi, Minami Akio, Yamashita Tadashi

Abstract excerpt

Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be a master cytokine in chronic, destructive arthritis. Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium...

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Identifiers

PMID: 22768242
DOI: 10.1371/journal.pone.0040136
PMCID: PMC3387008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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